Principal Investigator

张研
神经退行性疾病中的细胞死亡机制研究、老年性痴呆症中的淀粉样蛋白毒性和代谢,神经元极性和生物标记物研究、老年痴呆症中轴突退行性病变的机制

联系电话:010-62754880
通信地址: 北京大学颐和园路5号
电子邮件:yanzhang@pku.edu.cn

张研,教授

 

研究兴趣:

以老年性痴呆症等典型记忆障碍为基本模型,研究神经元退行性病变的机制,特别是轴突、髓鞘、轴突起始节等结构在老年性痴呆症模型中的异常和可塑性变化,以及这些可塑性变化对长时程增强(LTP)和形成LTP的神经环路的影响,在此基础上深入研究结构变化和可塑性发生的分子机制。

 

 

代表性科研论文:

1. Sun X, Wu Y, Gu M, Liu Z, Ma Y, Li J, Zhang Y*. Selective filtering defect at the axon initial segment in Alzheimer’s disease mouse models. 2014, PNAS, 111: 14271-14276.

2. Finci LI, Krüger N, Sun X, Zhang J, Chegkazi M, Wu Y, Schenk G, Mertens HDT, Svergun DI, Zhang Y*, Wang J-H*, Meijers R*. The crystal structure of netrin-1 in complex with DCC reveals the bi-functionality of netrin-1 as a guidance cue. 2014, Neuron, 83: 839-849.

3. Sun X, Wu Y, Gu M, Zhang Y*. MiR-342-5p decreases ankyrin G level in Alzheimer’s disease transgenic mouse models. 2014, Cell Reports, 6: 264-270.

4. Cui J, Wang Y, Dong Q, Wu S, Xiao X, Hu J, Chai Z* and Zhang Y*. Morphine protects against intracellular amyloid toxicity by inducing estradiol release and upregulation of Hsp70. 2011, J Neurosci, 31: 16277-16240.

5. Wang Y, Cui J, Sun X and Zhang Y*. Tunneling-nanotube development in astrocytes depends on p53 activation. 2011, Cell Death Differ, 18: 732-742.

 

 

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