Principal Investigator

Lin Lu
Pathogenesis of Psychiatry Disorders




Research Interests:

Psychiatric disorders (such as substance addiction, depression) have been one of the greatest threats to human health. The Lu’s laboratory investigates the neurobiological mechanisms and clinical intervention measures of substance addiction and depression. Using methods of molecular biology, pharmacology, electrophysiology, molecular genetics, psychology and neural imaging in animal (rats and mice) and human (depression patients and addicts), we aim to study (1) aberrant synaptic plasticity of depression and drug dependence; (2) the molecular mechanisms of dynamic pathological memory; (3) psychological and cognitive changes of depression patients and drug addicts, as well as the pharmacological and behavioral intervention measures.



Selected Publications:

  1. Bao YP, Sun Y, Meng SQ, Shi J, Lu L. 2019-nCoV epidemic: address mental health care to empower society. Lancet. 2020; 395(10224):e37-e38.
  2. Liu JJ, Bao YP, Huang XL, Shi J, Lu L. Mental health considerations for children quarantined because of COVID-19. Lancet Child Adolescent Health. 2020; 4(5):347-349.
  3. Bao YP, Meng SQ, Sun Y, Shi J, Lu L. Healthy China Action plan empowers child and adolescent health and wellbeing. Lancet Public Health. 2020; 4(9):e448.
  4. Shi L, Lu ZA, Que JY, Huang XL, Liu L, Ran MS, Gong YM, Yuan K, Yan W, Sun YK, Shi J, Bao YP, Lu L. Prevalence of and risk factors associated with mental health symptoms among the general population in China during the Coronavirus Disease 2019 Pandemic. JAMA Netw Open. 2020; 3(7):e2014053.
  5. Li SX, Han Y, Xu LZ, Yuan K, Zhang RX, Sun CY, Xu DF, Yuan M, Deng JH, Meng SQ, Gao XJ, Wen Q, Liu LJ, Zhu WL, Xue YX, Zhao M, Shi J, Lu L. Uncoupling DAPK1 from NMDA receptor GluN2B subunit exerts rapid antidepressant-like effects. Mol Psychiatry. 2018; 23(3):597-608.
  6. Yan W, Liu JF, Han Y, Zhang W, Luo YX, Xue YX, Zhu WL, Yang C, Chen WH, Guo HL, Ma YN, Yuan K, Wang JS, Shi J, Lu L. Protein kinase Mζ in medial prefrontal cortex mediates depressive-like behavior and antidepressant response. Mol Psychiatry. 2018; 23(9):1878-1891.
  7. Xue YX, Deng JH, Chen YY, Zhang LB, Wu P, Huang GD, Luo YX, Bao YP, Wang YM, Shaham Y, Shi J, Lu L. Effect of selective inhibition of reactivated nicotine-associated memories with propranolol on nicotine craving. JAMA Psychiatry. 2017; 74(3):224-232.
  8. Xue YX, Chen YY, Zhang LB, Zhang LQ, Huang GD, Sun SC, Deng JH, Luo YX, Bao YP, Wu P, Han Y, Hope BT, Shaham Y, Shi J, Lu L. Selective inhibition of amygdala neuronal ensembles encoding nicotine-associated memories inhibits nicotine preference and relapse. Biol Psychiatry. 2017; 82(11):781-793.
  9. Luo YX, Xue YX, Liu JF, Shi HS, Jian M, Han Y, Zhu WL, Bao YP, Wu P, Ding ZB, Shen HW, Shi J, Shaham Y, Lu L. A novel UCS memory retrieval-extinction procedure to inhibit relapse to drug seeking. Nat Commun. 2015; 6:7675.
  10. Xue YX, Luo YX, Wu P, Shi HS, Xue LF, Chen C, Zhu WL, Ding ZB, Bao YP, Shi J, Epstein DH, Shaham Y, Lu L. A memory retrieval-extinction procedure to prevent drug craving and relapse. Science. 2012; 336(6078):241-5.