Principal Investigator

Weihua Yue
Genetic Susceptibility of Mental Illness


Research Interests:

Prof. Yue’s lab has been committed to finding the susceptibility genes of common mental disorders (such as schizophrenia, major depressive disorder, autism spectrum disorder, bipolar disorder, etc.) in Chinese Han population. The major academic performances of the applicant are as follows: 1) Using the genome-wide association study (GWAS) and meta- analysis across East Asian and PGC Caucasian populations, to explore novel susceptible loci of mental disorders. They will further explore the potential function of the novel susceptible genes using the animal models. 2) Using the multi-omics approaches (with clinic- psychological- GWAS- mRNA- microRNA data), they evaluate the potential interactive effects of genetic polymorphisms or variants, on transcriptional levels or neuroimaging characters in psychiatric patients. They also explored the gene-environmental interactive effects on subjects’ cognition and mood status, considering the urbanization. 3) With a relatively large sample size of pharmacogenomics, they further search susceptible genes associated with individual differences in therapeutic or side effects of common antipsychotic medicines. The efficacy prediction model, combining the polygenic risk score (PRS) and poly-methylation score (PMS), can be helpful to predict the individualized therapeutic effects of antipsychotics.


Selected Publications:

  1. Guo L, Su Y, Zhang Y, Yu H, Lu Z, Li W, Yang Y, Xiao X, Yan H, Lu T, Li J, Liao Y, Kang Z, Wang L, Li Y, Li M, Liu B, Huang H, Lv L, Yao Y, Tan Y, Breen G, Everall I, Wang H, Huang Z*, Zhang D*, Yue W*. (2023) Prediction of treatment response to antipsychotic drugs for precision medicine of schizophrenia: randomized trials and multi-omics analysis. Mil Med Res. 10(1):24.
  2. Hu S#, Li H#, Yu H#, Liu Y#, Liu C, Zuo X, Lu J, Xi C, Huang B, Jiang J, Xu H, Hu J, Lai J, Huang M, Liu J, Xu D,  Guo X, Wu W, Wu X, Jiang J, Li M, Zhang G, Huang J, Wei N, Lv W, Duan J, Qi H, Hu C, Chen J, Zhou W, Xu W, Liu C, Liang H, Du J, Zheng S, Lu Q, Zheng L, Hu X, Chen F, Chen P, Zhu B, Xu L, Ni Z, Fang Y, Yang Z, Shan X, Zheng E, Zhang F, Zhou Q, Rao Y, Swaab D, Yue W*, Xu Y*. (2021) Discovery of new genetic locus for male sexual orientation in Han population. Cell Discov. 7(1):103.
  3. Lam M#, Chen C#, Li Z, Martin A, Bryois J, Ma X, Gaspar H, Ikeda M, Benyamin B, Brown B, Liu R, Zhou W, Guan L, Kamatani Y, Kim S, Kubo M, Kusumawardhani A, Liu C, Ma H, Periyasamy S, Takahashi A, Wang Q, Xu Z, Yu H, Zhu F, Psychiatric Genomics Consortium - Schizophrenia Working Group†, Indonesia Schizophrenia Consortium, Genetic, REsearch on schizophrenia neTwork-China and Netherland (GREAT-CN), Chen W, Faraone S, Glatt S, He L, Hyman S, Hwu H, Li T, McCarroll S, Neale B, Sklar P, Wildenauer D, Yu X, Zhang D, Mowry B, Lee J, Holmans P, Xu S, Sullivan P, Ripke S, O’Donovan M, Daly M, Qin S, Sham P, Iwata N, Hong K, Schwab S, Yue W*, Tsuang M*, Liu J*, Ma X*, Kahn R*, Shi Y*, Huang H*. (2019) Comparative genetic architectures of schizophrenia in East Asian and European populations. Nat Genet. 51(12): 1670-1678.
  4. Lu Z, Zhang Y, Sun Y, Liao Y, Kang Z, Feng X, Yan H, Li J, Wang L, Lu T, Zhang D, Yue W*. (2023) Therapeutic outcomes wide association scan (TOWAS) of different antipsychotics in schizophrenia. Psychiatry Clin Neurosci. May 21. doi: 10.1111/pcn.13567. Online ahead of print.
  5. Lu Z#, Zhang Y#, Sun Y, Liao Y, Kang Z, Feng X, Yan H, Li J, Wang L, Lu T, Zhang D, Huang Y*, Yue W*. (2023) The positive association between antipsychotic-induced weight gain and therapeutic response: new biotypes of schizophrenia. Psychiatry Res. 324:115226.
  6. Lv H#, Li J#, Gao K, Zeng L, Xue R, Liu X, Zhou C, Yue W*, Yu H*. (2022) Identification of genetic loci that overlap between schizophrenia and metabolic syndrome. Psychiatry Res. 318: 114947.
  7. Dong L#, Yan H#, Huang X#, Hu X, Yang Y, Ma C, Du B, Lu T, Jin C, Wang L, Yu H, Dong Z, Li W, Ruan Y, Zhang H, Zhang H, Mi W, Ma W, Li K, Lv L, Zhang D, Yue W*. (2015) A2BP1 gene polymorphisms association with olanzapine-induced weight gain. Pharmacol Res 99: 155-161.
  8. Yu H, Yan H, Wang L, Li J, Tan L, Deng W, Chen Q, Yang G, Zhang F, Lu T, Yang J, Li K, Lv L, Tan Q, Zhang H, Xiao X, Li M, Ma X, Yang F, Li L, Wang C, Li T, Zhang D, Yue W*, Chinese Antipsychotics Pharmacogenomics Consortium. (2018) Five novel loci associated with antipsychotic treatment response in patients with schizophrenia: a genome-wide association study. Lancet Psychiatry 5(4):327-338.
  9. Yu H, Liu C, Li Z, Zhang X, Cai L, Wang Q, Iwata N, Ikeda M, Yan H, Wang L, Lu T, Chinese Schizophrenia Genetics Group, Li T, Liu B, Shi Y, Zhang D, Yue W*. (2017) Common variants on 2p16.1, 6p22.1 and 10q24.32 are associated with schizophrenia in Chinese Han population. Mol Psychiatry 22(7):954-960.
  10.  Yue WH#, Wang HF, Sun LD#, Tang FL, Liu ZH, Zhang HX, Li WQ, Zhang YL, Zhang Y, Ma CC, Du B, Wang LF, Ren YQ, Yang YF, Hu XF, Wang Y, Deng W, Tan LW, Tan YL, Chen Q, Xu GM, Yang GG, Zuo XB, Yan H, Ruan YY, Lu TL, Han X, Ma XH, Wang Y, Cai LW, Jin C, Zhang HY, Yan J, Mi WF, Yin XY, Ma WB, Liu Q, Kang L, Sun W, Pan CY, Shuang M, Yang FD, Wang CY, Yang JL, Li KQ, Ma X, Li LJ, Yu X, Li QZ, Huang X, Lv LX, Li T, Zhao GP, Huang W*, Zhang XJ, Zhang D*. (2011) Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. Nat Genet 43(12): 1228-1231.