Principal Investigator

Yonglu Tian
Neuropsychiatric disorders, Neural microcircuits, Two-photon imaging in awake animal, Behavioral evaluation in animal model

address: No.5 Yiheyuan Road, Haidian District, Beijing. 100871




Research Interests:

My research interests focus on the neural circuit changes underlying the diseased brain, especially autism spectrum disorders (ASDs) and Alzheimer's disease (AD). In previous work, using in vivo two-photon Ca(2+) imaging techniques, we found deficits of neural circuit function in the primary visual cortex (V1) of ASD mice model and in the prefrontal cortex (PFC) of young AD mice. In the future, I plan to use the in vivo two-photon Ca(2+) imaging technology to study the spatial temporal properties of neural circuits in awake animals with neuropsychiatric diseases, and to explore the neural circuit mechanisms of these diseases.



Selected Publications:

Main Research Articles:

Yang C#, Tian Y#, Su F#, Wang Y#, Liu M#, Wang H#, Cui Y#, Yuan P, Li X, Li A, Gong H, Luo Q, Zhu D, Cao P, Liu Y, Wang X, Luo MH, Xu F, Xiong W, Wang L, Li XY, Zhang C*. (2021) Restoration of FMRP expression in adult V1 neurons rescues visual deficits in a mouse model of fragile X syndrome. Protein Cell. 13(3):203-219. (#co-first authors)

Wang Y#, Su F#, Wang S#, Yang C#, Tian Y#, Yuan P#, Liu X, Xiong W*, Zhang C*. (2019) Efficient implementation of convolutional neural networks in the data processing of two-photon in vivo imaging. Bioinformatics.35(17):3208-3210. (#co-first authors) (*co-corresponding authors)

Tian Y#, Yang C#, Cui Y#, Su F#, Wang Y#, Wang Y#, Yuan P, Shang S, Li H, Zhao J, Zhu D, Tang S, Cao P, Liu Y, Wang X, Wang L, Zeng W, Jiang H, Zhao F, Luo M, Xiong W, Qiu Z*, Li XY*, Zhang C*. (2018) An Excitatory Neural Assembly Encodes Short-Term Memory in the Prefrontal Cortex. Cell Reports. 22(7):1734-1744. (#co-first authors) (*co-corresponding authors)

Tian Y#, Yang C#, Shang S#, Cai Y#, Deng X#, Zhang J, Shao F, Zhu D, Liu Y, Chen G, Liang J*, Sun Q*, Qiu Z*, Zhang C*. (2017) Loss of FMRP Impaired Hippocampal Long-Term Plasticity and Spatial Learning in Rats. Frontiers in Molecular Neuroscience.10:269. (#co-first authors) (*co-corresponding authors)

Collaborative Publications:

Ma D, Wang F, Wang R, Hu Y, Chen Z, Huang N, Tian Y, Xia Y, Teng J, Chen J. (2022) α-/γ-Taxilin are required for centriolar subdistal appendage assembly and microtubule organization. Elife. 11:e73252.

Zhu D, Xu R, Huang X, Tang Z, Tian Y, Zhang J, Zheng X. (2021) Deubiquitinating enzyme OTUB1 promotes cancer cell immunosuppression via preventing ER-associated degradation of immune checkpoint protein PD-L1. Cell Death and Differentiation. 28(6):1773-1789.

Xu R, Yu S, Zhu D, Huang X, Xu Y, Lao Y, Tian Y, Zhang J, Tang Z, Zhang Z, Yi J, Zhu HH, Zheng X. (2019) hCINAP regulates the DNA-damage response and mediates the resistance of acute myelocytic leukemia cells to therapy. Nature Communications.10(1):3812.

Zhou K, Ding Y, Vuletic I, Tian Y, Li J, Liu J, Huang Y, Sun H, Li C, Ren Q, Lu Y. (2018) In vivo long-term investigation of tumor bearing mKate2 by an in-house fluorescence molecular imaging system. Biomedical Engineering Online. 17(1):187.

Ji Y, Yang C, Tang Z, Yang Y, Tian Y, Yao H, Zhu X, Zhang Z, Ji J, Zheng X. (2017) Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation. Nature Communications. 8:15308. 

Zeng WB, Jiang HF, Gang YD, Song YG, Shen ZZ, Yang H, Dong X, Tian YL, Ni RJ, Liu Y, Tang N, Li X, Jiang X, Gao D, Androulakis M, He XB, Xia HM, Ming YZ, Lu Y, Zhou JN, Zhang C, Xia XS, Shu Y, Zeng SQ, Xu F, Zhao F, Luo MH. (2017) Anterograde monosynaptic transneuronal tracers derived from herpes simplex virus 1 strain H129. Molecular Neurodegeneration. 12(1):38. 

Yu J, Ju Y, Zhao L, Chu X, Yang W, Tian Y, Sheng F, Lin J, Liu F, Dong Y, Hou Y. (2016) Multistimuli-Regulated Photochemothermal Cancer Therapy Remotely Controlled via Fe5C2 Nanoparticles. ACS Nano. 10(1):159-69. 

Bai D, Zhang J, Li T, Hang R, Liu Y, Tian Y, Huang D, Qu L, Cao X, Ji J, Zheng X. (2016) The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth. Nature Communications.7:12310. 

Weng R, Shen S, Burton C, Yang L, Nie H, Tian Y, Bai Y, Liu H. (2016) Lipidomic profiling of tryptophan hydroxylase 2 knockout mice reveals novel lipid biomarkers associated with serotonin deficiency. Analytical and Bioanalytical Chemistry. 408(11):2963-73.

Weng R, Shen S, Tian Y, Burton C, Xu X, Liu Y, Chang C, Bai Y, Liu H. (2015) Metabolomics Approach Reveals Integrated Metabolic Network Associated with Serotonin Deficiency. Scientific Reports. 5:11864.

Weng R, Shen S, Yang L, Li M, Tian Y, Bai Y, Liu H. (2015) Lipidomic analysis of p-chlorophenylalanine-treated mice using continuous-flow two-dimensional liquid chromatography/quadrupole time-of-flight mass spectrometry. Rapid Communications in Mass Spectrometry. 2015 Aug 30;29(16):1491-500.

Zhong W, Zhu H, Sheng F, Tian Y, Zhou J, Chen Y, Li S, Lin J. (2014) Activation of the MAPK11/12/13/14 (p38 MAPK) pathway regulates the transcription of autophagy genes in response to oxidative stress induced by a novel copper complex in HeLa cells. Autophagy. 10(7):1285-300. 

Shen H, Zhu H, Song M, Tian Y, Huang Y, Zheng H, Cao R, Lin J, Bi Z, Zhong W. (2014) A selenosemicarbazone complex with copper efficiently down-regulates the 90-kDa heat shock protein HSP90AA1 and its client proteins in cancer cells. BMC Cancer. 14:629. 

Zhang Z, Jia C, Hu Y, Sun L, Jiao J, Zhao L, Zhu D, Li J, Tian Y, Bai H, Li R, Hu J. (2012) The estrogenic potential of salicylate esters and their possible risks in foods and cosmetics. Toxicology Letters. 209(2):146-53.