Principal Investigator

Yong Zhang
Synaptic Plasticity, AMPA Receptor, Trafficking, In Vivo Two Photon Imaging

address: Neuroscinece Research Institute, Peking University 38 Xueyuan Road, Haidian district,Beijing, 100191


Research Interests:

1. Elucidate molecular mechanisms underlying AMPA receptor synaptic plasticity,learning and memory,and animal behavior
2. Investigate AMPA receptor plasticity dysfunction and its role in pathogenesis of neurological and psychiatric diseases like Depression, Alzheimers’ disease, etc.


Selected Publications:

1. Zhou R, Li J, Chen Z, Wang R, Shen Y, Zhang R, Zhou F*, Zhang Y*. (2023). Pathological hemodynamic changes and leukocyte transmigration disrupt the blood–spinal cord barrier after spinal cord injury. J Neuroinflammation. 20(1):118.

2. Liu Z#, Ma H#, Long S, Zhang Y*. (2022). Metabotropic Glutamate Receptor 5: a Potential Molecular Switch and Beyond. Biol Psychiatry. 92:98-99.  

3. Ma H, Li CY, Wang JP, Zhang XC, Li MY, Zhang R, Huang Z, Zhang Y*. (2021). Amygdala-hippocampal innervation modulates stress-induced depressive-like behaviors through AMPA receptors. Proc Natl Acad Sci U S A. 118(6): e2019409118.

4. Chen J#, Zhang XC#, Li LP#, Ma XQ, Yang CX, Liu ZD, Li CY, Fernandez-Cabezudo M, al-Ramadi BK, Wu C, Huang WS, Zhang Y*, Zhang YH*, Liu WL*. (2021). Farnesyl pyrophosphate is a new danger signal inducing acute cell death. PLOS Biol. 19(4): e3001134.

5. Roth RH, Cudmore R, Tan H, Hong I, Zhang Y, Huganir RL*. (2020). Cortical Synaptic AMPA Receptor Plasticity During Motor Learning. Neuron. 105: 895-908.

6. Mehta S#*, Zhang Y#, Roth RH#, Zhang JF, Mo A, Tenner B, Huganir RL*, Zhang J*. (2018). A Suite of Single-fluorophore Biosensors for Sensitive and Multiplexed Detection of Signaling Activities. Nat Cell Biol. 20:1215-1225.

7. Roth RH#, Zhang Y#, Huganir RL*. (2017). Dynamic imaging of AMPA receptor trafficking in vitro and in vivo. Curr Opin Neurobiol. 45: 51-58.

8. Zhang Y#, Cudmore R#, Lin DT, Linden DJ, and Huganir RL*. (2015). Visualization of NMDA receptor-dependent AMPA receptor synaptic plasticity in vivo. Nat Neurosci. 18: 402-407.

9. Sharma K, Choi SY, Zhang Y, Nieland T, Long S, Li M, and Huganir RL*. (2013). High-throughput Genetic Screen for Synaptogenic Factors: Identification of LRP6 as Critical for Excitatory Synapse Development. Cell Rep. 5: 1330-1341.

10. Zhang Y#, Gao X#, Saucedo L, Ru B, Edgar B, and Pan D*. (2003). Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat Cell Biol. 5: 578-581.

11. Gao X#, Zhang Y#, Arrazola P, Hino O, Kobayashi T, Yeung R, Ru B, and Pan D*. (2002). Tsc tumor suppressor proteins antagonize amino-acid-TOR signaling. Nat Cell Biol. 4: 699-704.


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