主题：Genetic dissection of p75 neurotrophin receptor signaling in mouse models of Alzheimer’s Disease
报告人：Prof. Carlos Ibanez, Professor, Department of Physiology, Yong Loo Lin School of Medicine, NUS
The p75 neurotrophin receptor (p75ntr) is a member of the Tumor Necrosis Factor Receptor (TNFR) Superfamily of “death receptors”. Neurotrophin binding to p75ntr can induce neuronal death, neurite dystrophy, synapse elimination and synaptic long term depression (LTD). It has therefore been regarded as a prominent contributor to neurodegenerative processes, such as those undergoing in Alzheimer’s Disease (AD). The role of p75ntr in AD is unclear, as it has been reported to contribute to both Aβ peptide clearance as well as Aβ-mediated neurodegeneration. This presentation will summarize the latest results of our team using mice carrying different alleles of p75ntr lacking distinct functions. Through this approach, we have unravelled a previously unknown, unexpected mechanism by which p75ntr regulates production of Aβ peptide, the main component of the amyloid plaques in AD.