主题：Circadian Regulation of Sleep and Arousal in Flies and Mammals

报告人：

Mark Wu, M.D., Ph.D.

Associate Professor in Neurology, Medicine, Genetic Medicine, and Neuroscience

Johns Hopkins University

时间：2019年4月2日，13:00-15:00

地点：北京大学王克桢楼1206会议室

摘要：

While the molecular underpinnings of the core circadian clock are now well-established, how this oscillator regulates downstream behaviors is less understood.  Arguably the most prominent of these downstream behaviors are sleep/wake states.  Over the past 5 years, our lab has been studying the molecular and circuit mechanisms by which the circadian clock regulates sleep and arousal.  From a large-scale forward genetic screen in Drosophila, we identified a novel molecule named WIDE AWAKE (WAKE).  We have shown that WAKE acts downstream of the clock to regulate sleep by rhythmically tuning the neural activity of arousal-promoting clock neurons.  We now show that these mechanisms are conserved in mice.  Moreover, using chemogenetic, optogenetic, and electrophysiological approaches, we have characterized the regulation and function of WAKE+ circuits in mice.  These data suggest that WAKE defines a novel fundamental arousal circuit that bidirectionally interacts with neuromodulatory networks. Together, these studies establish conserved mechanisms by which the circadian clock regulates sleep and reveal a new neural network that is essential for arousal.

邀请人：饶毅 教授