主讲： Greg S. B. Suh, Ph.D.
Professor，Department of Biological Sciences Korean Advanced Institute of Science and Technology Daejeon, South Korea
题目: Interoceptive Glucose Sensing in Flies and Mice
主持: 李毓龙 教授
Glucose-sensing neurons respond to glucose or its metabolites, which act as signaling cues to regulate their neuronal activity. My laboratory in NYU and currently in KAIST have been able to elucidate that:
1）the nutritional content of sugar, rather than its palatability, was detected by a discrete population of glucose-excited neurons (termed DH44 neurons in flies and a subset of CRF neurons in mice) that promote sugar consumption;
2）the function of the glucose-sensing DH44 neurons is modulated by hunger state through the inputs from peripheral organs;
3）a pair of glucose-excited neurons (termed CN neurons) regulate two key endocrine axes: insulin and glucagon.