主讲：占成教授，中国科学技术大学

题目：摄食行为的神经机制及免疫调控

时间：12月8日（周五）10:00-11:30

地点：金光楼101报告厅

主持：李毓龙 / 董辉

报告摘要

Food intake is a fundamental need for animals and humans, serving as the basis for survival and other higher-level needs. As one of the most essential innate behaviors, feeding is regulated by the nervous system. Over the past few decades, advancements have revealed multiple brain regions and neurons involved in the regulation of feeding, particularly the classical hypothalamic nuclei and their circuits that play a crucial role in feeding behavior regulation. In recent years, emerging evidences have discovered the significant involvement of the brainstem in regulating feeding behavior and energy metabolism. On the other hand, feeding behavior has important impacts on metabolic health, the immune system, and even aging and longevity. We are particularly interested in the relationship between feeding and inflammation and immunity. By utilizing techniques such as optogenetics / chemogenetics, behavioral studies, flow cytometry, and optical imaging, we have studied the neuronal mechanisms through which dietary restriction influences immune functions in the context of autoimmune diseases. Our findings reveal that a subset of appetite-promoting neurons in the brainstem possesses the ability to inhibit autoimmune diseases and excessive inflammatory responses. Additionally, we have elucidated the corresponding neural circuits and molecular mechanisms involved.

主讲简介  

占成，中国科学技术大学教授，博士生导师。主要研究方向为摄食行为与能量代谢的神经调控机制。近年来，实验室主要针对神经-代谢-免疫的交互作用机制和功能开展研究。作为主要课题负责人承担包括国家科技创新2030“脑科学与类脑研究”重大项目和国家自然科学基金青年基金、国家自然科学基金优秀青年基金、国家自然科学基金面上项目、中科院百人计划等科研项目；发表学术论文20余篇，被引用1800余次，主要研究成果以通讯作者身份发表于Neuron，Current Biology, PNAS，Cell Reports, Journal of NeuroScience等国际知名杂志上，单篇最高引用450余次。中国神经科学学会应激分会委员，中国生理学会青年委员会委员，中国生理学会自主神经分会委员。