Principal Investigator

罗冬根
感知和动物行为、感光信号转导和编码、昼夜节律/睡眠、神经环路、化学感知、视觉、果蝇

联系电话：62760611
通信地址：
电子邮件：dgluo@pku.edu.cn

罗冬根，研究员

 

研究兴趣：

       我们研究动物感知和行为的神经机制，包括：(1)感觉神经系统如何将物理/化学刺激转导为神经电信号；(2)大脑编码、加工感觉信号的基本原理; (3)节律行为如生物钟、睡眠/觉醒和进食的神经机制。

       应用电生理方法（活体动物大脑神经元的多电极膜片钳记录等），结合分子遗传学、活体动物大脑双光子钙成像、动物行为学等方法，从分子、细胞、环路到整体动物行为多层次系统地研究动物感知和行为的基本规律。

 

代表性科研论文：

  1. Xiao N, Xu S, Li ZK, Tang M, Mao R, Yang T, Ma SX, Wang PH, Li MT, Sunikumar A, Rouyer F, Cao LH, and Luo DG (2023) A single photoreceptor splits perception and entrainment by cotransmission. Nature (in press).
  2. Tang M, Cao LH, Yang T, Ma SX, Jing BY, Xiao N, Xu S, Leng KR, Yang D, Li MT, and Luo DG (2022) An extra-clock ultradian brain oscillator sustains circadian timekeeping. Science Advances 8. Eabo5506.
  3. Luo DG, Silverman D, Frederiksen R, Adhikari R, Cao LH, Oatis JE, Kono M, Cornwall MC, and Yau KW. (2020) Apo-opsin and its dark constitutive activity across retinal cone subtypes. Current Biology 30, 4921-4931.
  4. Zhou Y, Cao LH, Sui XW, Guo XQ, and Luo DG (2019) Mechanosensory circuits coordinate two opposing motor actions in Drosophila feeding. Science Advances 5. Eaaw5141.
  5. Li MT, Cao LH, Xiao N, Tang M, Deng BW, Yoshii T, Yang T, and Luo DG (2018) Hub-organized parallel circuits of central circadian pacemakers for visual photoentrainment. Nature Communications 9: 4247.
  6. Cao LH, Yang D, Wu W, Zeng XK, Jing BY, Li MT, Qin SS, Tang C, Tu YH, and Luo DG (2017) Odorant-induced inhibition of olfactory sensory neurons drives olfactory perception in Drosophila. Nature Communications 8:1357.
  7. Yue WW, Frederiksen R, Ren X, Luo DG, et al. (2017) Spontaneous activation of visual pigments in relation to openness/closedness of chromophore-binding pocket. Elife e18492.
  8. Cao LH, Jing BY, Yang D, Zeng X, Shen Y, Tu Y, and Luo DG (2016) Distinct signaling of Drosophila chemoreceptors in olfactory sensory neurons. Proc. Natl. Acad. Sci. USA 113, E902-E911. 
  9. Cao LH, Luo DG, and Yau KW (2014) Light responses of primate and other mammalian cones. Proc. Natl. Acad. Sci. USA 111, 2752-2757. 
  10. Luo DG*, Yue WWS, Ala-Laurila P and Yau KW* (2011) Activation of visual pigments by light and heat. Science 332, 1037-1312. (*Co-corresponding Authors)
  11. Fu Y*, Vladimir K*, Luo DG*, Xue T* and Yau KW (2008) Quantal noise from human red cone pigment. Nature Neuroscience 11, 565-571. (* Equal Contributions).
  12. Luo DG, Xue T and Yau KW (2008) How vision begins: an odyssey. Proc. Natl. Acad. Sci. USA 105, 9855-9862.
  13. Su CY, Luo DG, Terakita A, Shichida Y, Liao HW, Kazmi MA, Sakmar TP and Yau KW (2006) Parietal-eye phototransduction components and their potential evolutionary implications. Science 311, 11617-11621.
  14. Luo DG and Yau KW (2005) Rod sensitivity of neonatal mouse and rat. J. Gen. Physiol. 126, 263-269.
  15. Fu YB, Zhong HN, Wang MH, Luo DG, Liao HW, Maeda H, Hattar S, Frishman LJ and Yau KW  (2005) Intrinsically photosensitive retinal ganglion cells detect light with a Vitamin A-based photopigment, melanopsin. Proc. Natl. Acad. Sci. USA 102, 10339-10344.
  16. Luo DG and Yang XL (2002) Suppression by zinc of transient OFF responses of carp amacrine cells to red light is mediated by GABAA receptors. Brain Research 958, 222-226.
  17. Luo DG, Li GL and Yang XL (2002) Zn2+ modulates light responses of color-opponent bipolar and amacrine cells in the carp retina. Brain Res. Bull. 58, 461-468.
  18. Luo DG and Yang XL (2001) Zn2+ differentially modulates signals from red- and short wavelength-sensitive cones to horizontal cells in carp retina. Brain Research 900, 95-102.
  19. Xu HP, Luo DG and Yang XL (2001) Signals from cone photoreceptors to L-type horizontal cells are differentially modulated by low calcium in carp retina. Eur. J. Neurosci. 13, 1411-1419.

 

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