Principal Investigator

陆林
精神疾病的发病机制

联系电话：
通信地址：
电子邮件：linlu@bjmu.edu.cn

陆林，教授

 

研究兴趣：

长期从事精神心理疾病及睡眠障碍的公共卫生政策、发病机制、流行病学特征和干预策略研究。具体包括：1）病理性记忆动态变化的分子生物学机制；2）抑郁症和药物依赖的脑内突触可塑性改变以及认知的变化规律及其干预手段；3）睡眠觉醒障碍的发病机制和干预方法研究。

 

代表性科研论文：

  1. Bao YP, Sun Y, Meng SQ, Shi J, Lu L. 2019-nCoV epidemic: address mental health care to empower society. Lancet. 2020; 395(10224):e37-e38.
  2. Liu JJ, Bao YP, Huang XL, Shi J, Lu L. Mental health considerations for children quarantined because of COVID-19. Lancet Child Adolescent Health. 2020; 4(5):347-349.
  3. Bao YP, Meng SQ, Sun Y, Shi J, Lu L. Healthy China Action plan empowers child and adolescent health and wellbeing. Lancet Public Health. 2020; 4(9):e448.
  4. Shi L, Lu ZA, Que JY, Huang XL, Liu L, Ran MS, Gong YM, Yuan K, Yan W, Sun YK, Shi J, Bao YP, Lu L. Prevalence of and risk factors associated with mental health symptoms among the general population in China during the Coronavirus Disease 2019 Pandemic. JAMA Netw Open. 2020; 3(7):e2014053.
  5. Li SX, Han Y, Xu LZ, Yuan K, Zhang RX, Sun CY, Xu DF, Yuan M, Deng JH, Meng SQ, Gao XJ, Wen Q, Liu LJ, Zhu WL, Xue YX, Zhao M, Shi J, Lu L. Uncoupling DAPK1 from NMDA receptor GluN2B subunit exerts rapid antidepressant-like effects. Mol Psychiatry. 2018; 23(3):597-608.
  6. Yan W, Liu JF, Han Y, Zhang W, Luo YX, Xue YX, Zhu WL, Yang C, Chen WH, Guo HL, Ma YN, Yuan K, Wang JS, Shi J, Lu L. Protein kinase Mζ in medial prefrontal cortex mediates depressive-like behavior and antidepressant response. Mol Psychiatry. 2018; 23(9):1878-1891.
  7. Xue YX, Deng JH, Chen YY, Zhang LB, Wu P, Huang GD, Luo YX, Bao YP, Wang YM, Shaham Y, Shi J, Lu L. Effect of selective inhibition of reactivated nicotine-associated memories with propranolol on nicotine craving. JAMA Psychiatry. 2017; 74(3):224-232.
  8. Xue YX, Chen YY, Zhang LB, Zhang LQ, Huang GD, Sun SC, Deng JH, Luo YX, Bao YP, Wu P, Han Y, Hope BT, Shaham Y, Shi J, Lu L. Selective inhibition of amygdala neuronal ensembles encoding nicotine-associated memories inhibits nicotine preference and relapse. Biol Psychiatry. 2017; 82(11):781-793.
  9. Luo YX, Xue YX, Liu JF, Shi HS, Jian M, Han Y, Zhu WL, Bao YP, Wu P, Ding ZB, Shen HW, Shi J, Shaham Y, Lu L. A novel UCS memory retrieval-extinction procedure to inhibit relapse to drug seeking. Nat Commun. 2015; 6:7675.
  10. Xue YX, Luo YX, Wu P, Shi HS, Xue LF, Chen C, Zhu WL, Ding ZB, Bao YP, Shi J, Epstein DH, Shaham Y, Lu L. A memory retrieval-extinction procedure to prevent drug craving and relapse. Science. 2012; 336(6078):241-5.