研究兴趣

王征课题组主要运用影像学和神经调控技术研究精神疾病的诊断与预后评估，特别是结合非人灵长类模型解析临床强迫症、物质成瘾等疾病的病理环路，实践探索灵长类动物模型向临床应用转化，推进精神疾病的影像学临床诊断，研创神经新技术开展干预调控。主要研究方向包括：

开展灵长类影像学和转录组学大数据研究，挖掘脑联接图谱的生物学基础；

重点解析强迫症、物质成瘾等相关精神疾病的环路机制，建立影像学指标评估优化认知行为、药物以及深部脑刺激等治疗方案的临床疗效；

利用基因编辑等多种技术手段建立灵长类动物疾病模型，同时并行开展临床研究（包括转录组学、行为学、影像学和神经调控干预），探索模式动物-人类临床试验相互的转化路径，发展跨物种智能算法辅助的精准诊断和治疗。

代表性科研论文

1. Zhang CC1, Kim S-G1, Li J, Zhang YY, Lv QM, Zeljic K, Gong HF, Wei HG, Liu WJ, Sun BM, Wang Z*, Voon V*., Anterior limb of the internal capsule tractography: relationship with capsulotomy outcomes in obsessive-compulsive disorder, Journal of Neurology, Neurosurgery, and Psychiatry, 2021, in press

2. Zhan YF1, Wei JZ1, Liang J, Xu X, He R*, Robbins TW, Wang Z.*, Diagnostic classification for human autism and obsessive-compulsive disorder based on machine learning from a primate genetic model, American Journal of Psychiatry, 2021, 178(1): 65-76. [Commentary by van den Heuvel OA, Can Transgenic monkeys help us innovate transdiagnostic therapies?  American Journal of Psychiatry, 2021, 178(1): 8-10.]

 3. Lv QM, Yan MC, Shen XY, Wu J, Yu WW, Yan SY, Yang F, Zeljic K, Shi YQ, Zhou ZF, Lv LB, Hu XT, Menon R, Wang Z.*, Normative analysis of individual brain differences based on a population MRI-based atlas of cynomolgus macaques, Cerebral Cortex, 2021, 31(1): 341-355.

4. Cai DC1, Wang ZW1, Bo TT1, Yan SY1, Liu YL, Liu ZW, Zeljic K, Chen XY, Zhan YF, Xu X, Du YS, Wang YW, Cang J, Wang GZ, Zhang J, Sun Q, Qiu ZL, Ge SJ*, Ye Z, Wang Z.*, MECP2 duplication causes aberrant GABA pathways, circuits and behaviors in transgenic monkeys: neural mappings to patients with autism, Journal of Neuroscience, 2020, 40(19): 3799-3814.

 5. Yin DZ1, Zhang CC1, Lv QM, Chen XY, Zeljic K, Gong HF, Zhan SK, Jin HY, Wang Z.*, Sun BM*, Dissociable frontostriatal connectivity: mechanism and predictor of the clinical efficacy of capsulotomy in obsessive-compulsive disorder, Biological Psychiatry, 2018, 84(12): 926-936. [Commentary by Hoexter MQ, Are we ready for individualized target planning of ablative procedures in intractable obsessive-compulsive disorder? Biological Psychiatry, 2018, 84(12): e85-e87]

6. Lv QM1, Wang Z1, Zhang CC1, Fan Q, Zeljic K, Sun BM, Xiao ZP*, Wang Z.*, Divergent structural responses to pharmacological interventions in orbitofronto-striato-thalamic and premotor circuits in obsessive-compulsive disorder, EBioMedicine, 2017, 22:242-248. 

7. Zhou TT1, Zhu H1, Fan ZX, Wang F, Chen Y, Liang HX, Yang ZF, Zhang L, Lin LN, Zhan Y, Wang Z, Hu H*, History of winning remodels thalamo-PFC circuit to reinforce social dominance, Science, 2017, 357: 162-168.

8. Yin DZ, Liu WJ, Zeljic K, Wang ZW, Lv Q, Fan MX, Cheng WH*, Wang Z*, Dissociable changes of frontal and parietal cortices in inherent functional flexibility across the human lifespan, Journal of Neuroscience, 2016, 36(39):10060-10074.

 9. Lv Q1, Yang LQ1, Li GL, Wang ZW, Shen ZM, Yu WW, Jiang QY, Hou BY, Pu J, Hu H*, Wang Z.*, Large-scale persistent network reconfiguration induced by ketamine in anesthetized macaques: relevance to mood disorders, Biological Psychiatry, 2016, 79: 765-775. [Commentary by Arnsten AF, Murray JD, Seo H, and Lee D. Ketamine’s antidepressant actions: potential mechanisms in the primate medial prefrontal circuits that represent aversive experience, Biological Psychiatry, 2016, 79: 713-715]

10. Pu J, Wang J, Yu WW, Shen ZM, Lv Q, Zeljic K, Zhang CC, Sun BM, Liu GX, Wang Z.*. Discriminative structured feature engineering for macroscale brain connectomes, IEEE Trans Med Imaging, 2015, 34(11):2333-2342.