Principal Investigator

杨竞
神经生物学、代谢生理学、免疫学

联系电话:
通信地址:
电子邮件:jyang@mail.rockefeller.edu

 

研究兴趣:

基于在神经生物学、生物化学和代谢生物学等方向的学科专长,我课题组的研究将着重阐释神经退行性疾病中神经元及神经元轴突病变分子机制中的多个重要问题:

(1)在退行性疾病条件下,神经元及神经元轴突如何对不同损伤产生应答反应?

(2)在受损神经元及神经元轴突中,代谢平衡的改变如何决定病变过程?

(3)在神经退行性疾病中,非神经元细胞(例如胶质细胞)如何参与病变过程?

 

 

代表性科研论文:

1. Yang J, Wu Z, Renier N, Simon DJ, Uryu K, Park DS, Greer PA, Tournier C, Davis RJ, and Tessier-Lavigne M., Pathological axonal death through a MAPK cascade that triggers a local energy deficit. Cell. 2015 Jan 15;160(1-2):161-76.

2. Renier N, Wu Z, Simon DJ, Yang J, Ariel P, and Tessier-Lavigne M., iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging. Cell. 2014 Nov 6;159(4):896-910.

3. Yang J*, Weimer RM*, Kallop D, Olsen O, Wu Z, Renier N, Uryu K, and Tessier-Lavigne M., Regulation of axon degeneration after injury and in development by the endogenous calpain inhibitor calpastatin. Neuron. 2013 Dec 4;80(5):1175-89. (* authors contributed equally)

4. Osterloh JM, Yang J, Rooney TM, Fox AN, Adalbert R, Powell EH, Sheehan AE, Avery MA, Hackett R, Logan MA, MacDonald JM, Ziegenfuss JS, Milde S, Hou YJ, Nathan C, Ding A, Brown RH Jr, Conforti L, Coleman M, Tessier-Lavigne M, Züchner S, and Freeman MR., dSarm/Sarm1 is required for activation of an injury-induced axon death pathway. Science. 2012 Jul 27;337(6093):481-4.

5. Yang J*, Zhao TJ*, Goldstein JL, and Brown MS., Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides. PNAS. 2008 Aug 5;105(31):10750-5. (*authors contributed equally)

6. Yang J, Brown MS, Liang G, Grishin NV, and Goldstein JL., Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell. 2008 Feb 8;132(3):387-96.

 

 

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