Principal Investigator

Carlos Ibanez
Studies of growth factor receptor signaling and physiology

联系电话:
通信地址: Room 326, Lui Che Woo Building, Peking University, No.5 Yiheyuan Road Haidian District, Beijing, P.R.China
电子邮件:carlos.ibanez@pku.edu.cn

 

Research Interests:

Carlos Ibanez studied biology at the University of Buenos Aires, Argentina. His PhD work was conducted at the Leloir Institute (formerly known as Fundacion Campomar) under the direction of Carlos Frasch. The papers published during his PhD are available HERE. Carlos Ibanez did postdoctoral studies at the Karolinska Institute (KI), Sweden, under the direction of the late Håkan Persson. The articles published during his postdoc is available HERE. In 1996, he became Professor in Neuroscience at the Department of Neuroscience, Karolinska Institute in Stockholm, Sweden. Information about his KI laboratory can be found HERE. Since 2004, Carlos Ibanez is a member of the Nobel Assembly at the Karolinska Institute, the body that awards the Nobel Prize in Physiology Or Medicine. In the Fall of 2012, Carlos Ibanez became jointly appointed as Professor at the Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore (NUS). Information about his NUS laboratory can be found HERE. In January 2020, he joined the McGovern Institute at the School of Life Sciences in Peking University and the Chinese Institute for Brain Research in Beijing, China, as a part-time faculty, where he is now building a new research group.

 

 

Selected Publications:

We do not yet have publications from the Beijing laboratories, as these are just being established. Please see our recent publications from our lab at the Karolinska Institute HERE and from the NUS lab in Singapore HERE.

 

1. Kisiswa, L., Fernandez-Suarez, D., Sergaki, M. C. and Ibáñez, C.F. (2018) RIP2 gates TRAF6 interaction with death receptor p75NTR to regulate cerebellar granule neuron survival. Cell Reports, 24, 1013-1024.

2. Goh, ETH.,  Lin, Z., Young Ahn, B., Lopes-Rodrigues, V., Ha Dang, N., Salim, S., Berger, B., Dymock, B., Senger, D.L. and Ibáñez, C.F. (2018) A small molecule targeting the transmembrane domain of death receptor p75NTR induces melanoma cell death and reduces tumor growth. Cell Chemical Biology, 25, 1485–1494.

3. Tann, J.Y., Wong, L.-W., Sajikumar, S. and Ibáñez, C.F. (2019) Abnormal TDP-43 function impairs activity-dependent BDNF secretion, synaptic plasticity and cognitive behavior through altered Sortilin splicing. The EMBO Journal, 10.15252/embj.2018100989.

4. Wong, L.-W., Tann, J.Y., Ibáñez, C.F. and Sajikumar, S. (2019) The p75 neurotrophin receptor is a necessary mediator of synaptic and behavioral changes in sleep deprivation. J. Neurosci., 39 (28) 5452-5465

5. Göngrich, C., Krapacher, F., Munguba, H., Fernandez-Suarez, D., Andersson, A., Hjerling-Leffler, J. and Ibáñez C.F. (2019) ALK4 coordinates extracellular and intrinsic signals to regulate development of cortical somatostatin interneurons. J. Cell Biol. 219 (1): doi.org/10.1083/jcb.201905002

6. Srivastava, R.K., Moliner, A., Lee, E.-S., Nickles, E., Sim, E., Liu, C., Schwarz, H. and Ibáñez C.F. CD137negatively regulates “browning” of white adipose tissue during cold exposure. J. Biol. Chem. (2020) jbc.AC119.011795.

 

 

Lab Website:

http://carlosibanezlab.se/PKU/