Principal Investigator

陆林
精神疾病的发病机制

联系电话:
通信地址:
电子邮件:linlu@bjmu.edu.cn

陆林,教授

 

研究兴趣:

神经精神疾病(如物质成瘾、抑郁症等)已成为二十一世纪危害人类健康的最主要疾病之一。陆林实验室研究抑郁症和药物依赖的神经生物学和临床治疗学。采用动物研究(大鼠及小鼠)及人体研究(抑郁症患者,药物成瘾者)相结合的模式,综合运用分子生物学、药理学、电生理、分子遗传学、心理学及神经影像学手段,探索 (1)抑郁症和药物依赖发病后的脑内突触可塑性改变;(2)病理性记忆动态变化的分子生物学机制;(3)抑郁症和药物依赖患者的心理、认知的变化规律及其干预手段。

 

 

代表性科研论文:

1. Xue YX, Luo YX, Wu P, Shi HS, Xue LF, Chen C, Zhu WL, Ding ZB, Bao YP, Shi J, Epstein DH, Shaham Y, Lu L.*(2012) A memory retrieval-extinction procedure to prevent drug craving and relapse. Science, 336(6078):241-5.

2. Zhang XL, Shi J, Zhao LY, Sun LL, Wang J, Wang GB, Epstein DH, Lu L.* (2011) Effects of Stress on Decision-Making Deficits in Formerly Heroin-Dependent Patients After Different Durations of Abstinence. Am J Psychiatry., 168(6):610-6.

3. Li YQ, Xue YX, He YY, Li FQ, Xue LF, Xu CM, Sacktor TC, Shaham Y, Lu L.*(2011) Inhibition of PKMzeta in nucleus accumbens core abolishes long-term drug reward memory. J Neurosci., 31(14):5436-46.

4. Li FQ, Xue YX, Wang JS, Fang Q, Li YQ, Zhu WL, He YY, Liu JF, Xue LF, Shaham Y, Lu L.*(2010) Basolateral amygdala cdk5 activity mediates consolidation and reconsolidation of memories for cocaine cues. J Neurosci., 30:10351-9.

5. Wang X, Luo YX, He YY, Li FQ, Shi HS, Xue LF, Xue YX, Lu L.* (2010 Sep 22) Nucleus accumbens core mammalian target of rapamycin signaling pathway is critical for cue-induced reinstatement of cocaine seeking in rats. J Neurosci., 30(38):12632-41

6. Li SX, Shi J, Epstein DH, Wang X, Zhang XL, Bao YP, Zhang D, Zhang XY, Kosten TR, Lu L.* (2009) Circadian Alteration in Neurobiology During 30 Days of Abstinence in Heroin Users. Biol Psychiatry, 65(10):905-12

7. Wang XY, Zhao M, Ghitza UE, Li YQ, Lu L.* (2008)  Stress impairs reconsolidation of drug memory via glucocorticoid receptors in the basolateral amygdala. J Neurosci., 28:5602-10.

8. Lu L., Hope BT, Dempsey J, Liu SY, Bossert JM, Shaham Y*.(2005) Central amygdala ERK signaling pathway is critical to incubation of cocaine craving. Nat Neurosci., 8:212-9.

 

 

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