Principal Investigator

岳伟华
精神疾病的遗传易感性研究

联系电话:
通信地址: 北京市海淀区花园北路51号, 北京大学第六医院(精神卫生研究所);邮编 100191
电子邮件:dryue@bjmu.edu.cn

  

研究兴趣:

  主要从事精神分裂症的遗传易感性研究,包括对发病风险和药物疗效基因的精细定位及功能注释、多组学验证分析,为阐明精神分裂症的发病机制和优化个体化治疗方案提供科学依据。主要发现:1)采用基因组学研究策略,发现并验证中国汉族人群精神分裂症的新型易感基因并解析其部分生物功能;2)利用多组学技术揭示遗传变异影响精神分裂症患者基因转录功能及脑影像学特征;3)在基因组水平发现抗精神病药疗效个体差异的新型靶基因且疗效预测效果良好,为阐释精神分裂症发病机制和指导合理用药提供了新思路。

  

  

代表性科研论文:

1. Yu H, Yan H, Wang L, Li J, Tan L, Deng W, Chen Q, Yang G, Zhang F, Lu T, Yang J, Li K, Lv L, Tan Q, Zhang H, Xiao X, Li M, Ma X, Yang F, Li L, Wang C, Li T, Zhang D, Yue W*, Chinese Antipsychotics Pharmacogenomics Consortium. (2018) Five novel loci associated with antipsychotic treatment response in patients with schizophrenia: a genome-wide association study. Lancet Psychiatry 5(4):327-338.

2. Yu H, Liu C, Li Z, Zhang X, Cai L, Wang Q, Iwata N, Ikeda M, Yan H, Wang L, Lu T, Chinese Schizophrenia Genetics Group, Li T, Liu B, Shi Y, Zhang D, Yue W*. (2017) Common variants on 2p16.1, 6p22.1 and 10q24.32 are associated with schizophrenia in Chinese Han population. Mol Psychiatry 22(7):954-960.

3. Xu Y#, Yue W#, Yao Shugart Y, Li S, Cai L, Li Q, Cheng Z, Wang G, Zhou Z, Jin C, Yuan J, Tian L, Wang J, Zhang K, Liu S, Song Y, Zhang F. (2016) Exploring transcription factors-microRNAs co-regulating networks in schizophrenia. Schizophr Bull 42(4):1037-45.

4. Yu H, Wang L, Lv L, Ma C, Du B, Lu T, Jin C, Yan H, Yang Y, Li W, Ruan Y, Zhang H, Zhang H, Mi W, Mowry B, Ma W, Li K, Zhang D, Yue W*. (2016) Genome-wide association study suggested the PTPRD polymorphisms were associated with weight gain effects of atypical antipsychotic medications. Schizophr Bull 42(3): 814-23.

5. Yue WH#, Wang HF, Sun LD#, Tang FL, Liu ZH, Zhang HX, Li WQ, Zhang YL, Zhang Y, Ma CC, Du B, Wang LF, Ren YQ, Yang YF, Hu XF, Wang Y, Deng W, Tan LW, Tan YL, Chen Q, Xu GM, Yang GG, Zuo XB, Yan H, Ruan YY, Lu TL, Han X, Ma XH, Wang Y, Cai LW, Jin C, Zhang HY, Yan J, Mi WF, Yin XY, Ma WB, Liu Q, Kang L, Sun W, Pan CY, Shuang M, Yang FD, Wang CY, Yang JL, Li KQ, Ma X, Li LJ, Yu X, Li QZ, Huang X, Lv LX, Li T, Zhao GP, Huang W*, Zhang XJ, Zhang D*. (2011) Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. Nat Genet 43(12): 1228-1231.

  

  

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