研究兴趣：

1. 睡眠呼吸暂停的神经调控机制

  睡眠呼吸暂停的发生关键在于上气道塌陷，为什么呼吸暂停只在睡眠时发生？明确是解剖结构异常还是功能改变引起直接决定是否需要手术治疗。通过建立人工气道在睡眠状态下测定发现睡眠时中枢调控功能降低是发病的关键，奠定了内科治疗的理论基础。动物实验和治疗反应进一步证实这可能与遗传及长期低氧继发的钝化反应有关。

2．发作性睡病等睡眠疾病的遗传免疫机制

  发作性睡病属于罕见病，是脑内食欲素神经元死亡所致。在近30年的研究中，构建了国际上最大的发作性睡病病例和资源数据库；建立了放免法测定脑脊液食欲素水平诊断睡病的方法；发现了国人的遗传易感基因且与免疫相关，证明上呼吸道感染特别是2009年H1N1甲型流感可以诱发睡病，是触发免疫反应的重要抗原；明确了流感病毒诱发睡病的外周及中枢免疫机制。以上结果为免疫治疗奠定了基础。此外，通过国际合作发现了周期性嗜睡（Kleine Levin Syndrome）及不宁腿综合征（Restless Leg Syndrome）的易感基因。

3．睡眠疾病的远程医疗系统构建

  通过筛选睡眠呼吸暂停的可穿戴设备，应用人工智能等技术建立了家庭远程医疗系统，验证了该体系的临床效能及医疗经济学价值，实现了转化应用，并在全国各地推广。

代表性科研论文：

1. Li Z, Yi H, Li Y, Yang J, Guo P, Han F. Identification and validation of a novel autophagy-related biomarker in obstructive sleep apnea syndrome. Sleep. 2025;48(4):zsae287. doi: 10.1093/sleep/zsae287. PMID: 39665515.

2. Xu L, Yi H, Pi M, Zhang C, Keenan BT, Glick HA, Dong X, Pack AI, Han F, Kuna ST. Telemedicine management of obstructive sleep apnea disorder in China: a randomized, controlled, non-inferiority trial. Sleep Breath. 2024 Jun;28(3):1173-1185. doi: 10.1007/s11325-024-02994-6. Epub 2024 Jan 16. PMID: 38225441.

3. Wang X, Xiao F, Wang Y, Deng X, Chen Z, Dong X, Wang W, Li C, Xu Z, Wu H, Yu H, Su C, Wang Z, Tang X, Lv Y, Li Y, Sun S, Huang J, Hao L, Wei X, Deng L, Huang YS, Zhang J, Wing YK, Zhang J, Mignot E, Han F, Yu H. Changed epidemiology of narcolepsy before, during, and after the 2009 H1N1 pandemic: a nationwide narcolepsy surveillance network study in mainland China, 1990-2017. Sleep. 2023;46(3):zsac325.

4. Liang R, Zhu W, Gao Y, Zhao C, Zhang C, Xu L, Zuo Y, Lv Y, Zhao M, Li C, Gao J, Mei J, Gong X, Zhang L, Shen S, Yang C, Ren J, Liu Y, Wang Z, Wang P, Zhou J, Wang F, Wu J, Chen J, Zhu Y, Zhang C, Dong X, Han F.  Clinical features, polysomnography, and genetics association study of restless legs syndrome in clinic based Chinese patients: A multicenter observational study. Sleep Med. 2024;117:123-130.

5. Han F, Lin L, Li J, Dong XS, Mignot E. Decreased incidence of childhood narcolepsy 2 years after the 2009 H1N1 winter flu pandemic. Ann Neurol. 2013;73(4):560. doi: 10.1002/ana.23799.

6. Han F, Lin L, Warby SC, Faraco J, Li J, Dong SX, An P, Zhao L, Wang LH, Li QY, Yan H, Gao ZC, Yuan Y, Strohl KP, Mignot E. Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in china. Ann Neurol. 2011;70:410-7.

7. Xiao F, Zhang J, Strohl K, Han F. Neurology met sleep medicine in 2018. Lancet Neurol. 2019;18(1):15-17. doi: 10.1016/S1474-4422(18)30459-9. PMID: 30563675.

8. Han F, Faraco J, Dong XS, Ollila HM, Lin L, Li J, An P, Wang S, Jiang KW, Gao ZC, Zhao L, Yan H, Liu YN, Li QH, Zhang XZ, Hu Y, Wang JY, Lu YH, Lu CJ, Zhou W, Hallmayer J, Huang YS, Strohl KP, Pollmächer T, Mignot E. Genome wide analysis ofnarcolepsy in China implicates novel immune loci and reveals changes inassociation prior to versus after the 2009 H1N1 influenza pandemic. PLoS Genet.2013;9(10):e1003880.

9. Han F, Mignot E, Wei YC, Dong SX, Li J, Lin L, An P, Wang LH, Wang JS, He MZ, Gao HY, Li M, Gao ZC, Strohl KP. Ventilatorychemoresponsiveness, narcolepsy-cataplexy, and HLA-DQB1*0602 status. Eur Respir J.2010,36(3):577-83.  

10. Fang Han, Shyam Subramanian，Edwin R. Price, Joseph Nadeau，Kingman P. Strohl. Periodic breathing in the mouse. Journal of Applied Physiology. 2002; 92(3):1133-40.

11. Han F, Chen E, Wei H, He Q, Ding D, Strohl KP. Treatment effects on carbon dioxide retention in patients with obstructive sleep apnea-hypopnea syndrome. Chest. 2001 Jun;119(6):1814-9. doi: 10.1378/chest.119.6.1814. PMID: 11399709.