Topic：Immunogenic Cell Death: The Good, the Bad and the Ugly

　　Speaker：Prof. Kaming Chan

　　Time：14:40-16:10，March 23rd 2023

　　Venue：Youcai Deng Lectrue Hall

　　Host：Prof. Liangyi Chen

　　Abstract

　　Immunogenic cell death (ICD) such as necroptosis, pyroptosis and ferroptosis promotes inflammation and is strongly associated with many disease pathologies. In addition to cell death, recent work indicates that ICD signal adaptors can often facilitate inflammation independent of cell death. Several key signal adaptors of ICD pathways are currently being tested as therapeutic targets in inflammatory diseases. Interestingly, an increasing number of pathogens have been found to encode inhibitors that interfere with host cell ICD. In this seminar, we will discuss the molecular mechanisms of ICD and their biological functions. We will also discuss strategies employed by pathogens to interfere with host cell ICD.