Principal Investigator

Fang Han
Genetic Mechanisms and Immune Regulation of Sleep Disorders including Narcolepsy, and Telemedicine Technologies for Sleep Apnea

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Research Interests:

 (1) Genetic study on restless leg syndrome, narcolepsy and other hypersomnia disorders; (2) The mechanisms of flu virus triggering immunological response in narcolepsy; (3) Neural control mechanism in sleep apnea and telemedicine in sleep disorders management

Selected Publications:

1. Li Z, Yi H, Li Y, Yang J, Guo P, Han F. Identification and validation of a novel autophagy-related biomarker in obstructive sleep apnea syndrome. Sleep. 2025;48(4):zsae287. doi: 10.1093/sleep/zsae287. PMID: 39665515.

2. Xu L, Yi H, Pi M, Zhang C, Keenan BT, Glick HA, Dong X, Pack AI, Han F, Kuna ST. Telemedicine management of obstructive sleep apnea disorder in China: a randomized, controlled, non-inferiority trial. Sleep Breath. 2024 Jun;28(3):1173-1185. doi: 10.1007/s11325-024-02994-6. Epub 2024 Jan 16. PMID: 38225441.

3. Wang X, Xiao F, Wang Y, Deng X, Chen Z, Dong X, Wang W, Li C, Xu Z, Wu H, Yu H, Su C, Wang Z, Tang X, Lv Y, Li Y, Sun S, Huang J, Hao L, Wei X, Deng L, Huang YS, Zhang J, Wing YK, Zhang J, Mignot E, Han F, Yu H. Changed epidemiology of narcolepsy before, during, and after the 2009 H1N1 pandemic: a nationwide narcolepsy surveillance network study in mainland China, 1990-2017. Sleep. 2023;46(3):zsac325.

4. Liang R, Zhu W, Gao Y, Zhao C, Zhang C, Xu L, Zuo Y, Lv Y, Zhao M, Li C, Gao J, Mei J, Gong X, Zhang L, Shen S, Yang C, Ren J, Liu Y, Wang Z, Wang P, Zhou J, Wang F, Wu J, Chen J, Zhu Y, Zhang C, Dong X, Han F.  Clinical features, polysomnography, and genetics association study of restless legs syndrome in clinic based Chinese patients: A multicenter observational study. Sleep Med. 2024;117:123-130.

5. Han F, Lin L, Li J, Dong XS, Mignot E. Decreased incidence of childhood narcolepsy 2 years after the 2009 H1N1 winter flu pandemic. Ann Neurol. 2013;73(4):560. doi: 10.1002/ana.23799.

6. Han F, Lin L, Warby SC, Faraco J, Li J, Dong SX, An P, Zhao L, Wang LH, Li QY, Yan H, Gao ZC, Yuan Y, Strohl KP, Mignot E. Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in china. Ann Neurol. 2011;70:410-7.

7. Xiao F, Zhang J, Strohl K, Han F. Neurology met sleep medicine in 2018. Lancet Neurol. 2019;18(1):15-17. doi: 10.1016/S1474-4422(18)30459-9. PMID: 30563675.

8. Han F, Faraco J, Dong XS, Ollila HM, Lin L, Li J, An P, Wang S, Jiang KW, Gao ZC, Zhao L, Yan H, Liu YN, Li QH, Zhang XZ, Hu Y, Wang JY, Lu YH, Lu CJ, Zhou W, Hallmayer J, Huang YS, Strohl KP, Pollmächer T, Mignot E. Genome wide analysis ofnarcolepsy in China implicates novel immune loci and reveals changes inassociation prior to versus after the 2009 H1N1 influenza pandemic. PLoS Genet.2013;9(10):e1003880.

9. Han F, Mignot E, Wei YC, Dong SX, Li J, Lin L, An P, Wang LH, Wang JS, He MZ, Gao HY, Li M, Gao ZC, Strohl KP. Ventilatorychemoresponsiveness, narcolepsy-cataplexy, and HLA-DQB1*0602 status. Eur Respir J.2010,36(3):577-83.  

10. Fang Han, Shyam Subramanian，Edwin R. Price, Joseph Nadeau，Kingman P. Strohl. Periodic breathing in the mouse. Journal of Applied Physiology. 2002; 92(3):1133-40.

11. Han F, Chen E, Wei H, He Q, Ding D, Strohl KP. Treatment effects on carbon dioxide retention in patients with obstructive sleep apnea-hypopnea syndrome. Chest. 2001 Jun;119(6):1814-9. doi: 10.1378/chest.119.6.1814. PMID: 11399709.