科学研究

科学进展

饶毅实验室在《Genetics》发表题为“Sleep need, the key regulator of sleep homeostasis, is both Indicated and controlled by phosphorylation of threonine 221 in salt inducible kinase 3”的研究论文，发现一个分子的单个位点的化学修饰同时是睡眠需求的监...
岳伟华课题组在《JAMA Network Open》发表了题为“Multigenetic pharmacogenomics-guided treatment vs treatment as usual among hospitalized men with schizophrenia: a randomized clinical trial”的研究论文。该研究经随机对照试验发现，MPGT选药策略的...
邹鹏课题组在PNAS杂志在线合作发表了最新研究成果“Orange/far-red hybrid voltage indicators with reduced phototoxicity enable reliable long-term imaging in neurons and cardiomyocytes”，合成光稳定性良好的环辛四烯（COT）修饰的花菁染料，搭配灵敏度优异的复合型膜电位探...
邹鹏课题组在《Cell Reports Methods》发表题为“Functional imaging-guided cell selection for evolving genetically encoded fluorescent indicators”的研究论文，报道了基于荧光成像的定向进化方法Faculae，实现了遗传编码远红色钙探针的多维度表型筛选与定向进化。
王韵课题组在《Cancer Letters》发表题为“CDYL knockdown reduces glioma development through an antitumor immune response in the tumor microenvironment”的研究论文。文章以胶质瘤最常见的组织细胞学类型星形胶质细胞瘤来源的临床样本组织和细胞系为研究对象，揭示了CDYL在胶质瘤发生发展...
方方课题组在《Current Biology》合作发表题为“Dyadic visual perceptual learning on orientation discrimination”的研究论文，运用功能磁共振脑成像与心理物理学实验，首次揭示了社会情境对于视觉知觉学习的促进作用以及相关的神经加工机制。
王征实验室在《Cell Reports》发表题为“Noncoding transcripts are linked to brain resting-state activity in non-human primates”的研究论文，报道了利用实验室前期收集的猕猴全脑分区、单细胞转录组图谱和静息态脑影像数据，整合分析发现150个非编码基因与蛋白编码基因一起共同调控大脑网络在静息状态下的同步自发振...
纳家勇治课题组在《PLOS Biology》期刊上发表题为“Sequential involvements of the perirhinal cortex and hippocampus in the recall of item-location associative memory in macaques”的研究论文，通过猕猴电生理研究揭示了语义记忆提取的两段式机制。方位记忆信息先由鼻周皮质...
岳伟华课题组在《Military Medical Research》在线发表了题为“Prediction of treatment response to antipsychotic drugs for precision medicine approach to schizophrenia: randomized trials and multiomics analysis”的研究，发现并验证了...
岳伟华课题组在《Psychiatry and Clinical Neurosciences 》发表题为“Therapeutic Outcomes Wide Association Scan of different antipsychotics in patients with schizophrenia: randomized clinical trials and multi-ancestry...